Mews Lab
Integrating Epigenetics and Metabolism to Unlock Brain Function
Welcome to the Mews Lab!
We investigate how metabolism and epigenetics come together to influence brain function and behavior. By focusing on neuroepigenetics and substance use disorders, we aim to uncover the molecular pathways that connect metabolic states to chromatin dynamics—the processes that control how DNA is packaged and genes are expressed. Our research seeks to understand how these mechanisms affect neural plasticity and cognitive performance, shedding light on how metabolic processes impact behavior and disease.
Research Focus.
How Metabolism
Shapes Brain Function
Our lab investigates how the body's metabolic states influence gene expression in the brain. Focusing on chromatin dynamics—the process by which neurons package and access DNA—we explore how metabolic signals and energy fluctuations switch genes on and off. Using state-of-the-art techniques like single-cell RNA sequencing and metabolomic profiling, we aim to uncover how this intricate relationship drives learning, memory, and cognitive flexibility. Our goal is to unlock novel strategies to enhance brain performance and combat neurodegenerative diseases.
How Drugs Change the Neuronal Epigenome
We explore how drugs like cocaine and alcohol cause profound, lasting changes in the brain’s genetic programming. By studying how these substances alter chromatin—the way DNA is packaged and read—we examine the epigenetic mechanisms that drive addiction. Utilizing advanced tools like ChIP-sequencing and mass spectrometry combined with behavioral models, we reveal how these drugs change gene expression, leading to long-term alterations in brain function and behavior. Our research seeks to uncover new therapeutic targets to reverse these changes and prevent addiction relapse.
How to Rewrite the Epigenetic Code
The Mews Lab is pioneering efforts to reverse harmful gene expression changes that contribute to addiction and mental health disorders. By precisely targeting the epigenetic markers controlling gene activity in neurons, we aim to reset abnormal gene expression patterns to a healthy state. Utilizing cutting-edge tools like CRISPR-based epigenome editing and epigenetic therapeutics, we aim to develop novel treatment paradigms to restore normal brain function. Our work holds exciting potential for next-generation therapies that can revolutionize the treatment of neuropsychiatric conditions.
Innovative
Technologies
that Unveil
Brain Mechanisms.
We harness state-of-the-art technologies to push the boundaries of neuroscience and epigenetics research. Our work integrates a range of innovative tools and approaches that allow us to dive deep into the molecular mechanisms driving brain function and behavior.
Single-Cell and
Spatial Sequencing
We utilize cutting-edge sequencing techniques, including single-cell RNA sequencing and spatial transcriptomics, to explore how individual brain cells respond to various stimuli, including substance use.
Big Data and Computational Approaches
We leverage advanced bioinformatics and computational modeling to make sense of complex datasets, linking genomic, epigenomic, and transcriptomic information with brain function and behavior.
Mass Spectrometry
Our lab employs innovative mass spectrometry-based approaches to quantify protein dynamics and modifications. These tools help us understand how changes at the protein level contribute to neuronal processes and brain function over time.
Advanced Mouse Models
We utilize sophisticated genetic mouse models to investigate the epigenetic and molecular underpinnings of behavior. These models allow us to manipulate specific genes or pathways and observe their effects on brain function, providing crucial insights into how genetic and environmental factors intersect in disorders like addiction.
Complex Behavioral Studies
Understanding behavior is central to our research. We conduct complex behavioral studies to examine how genetic and epigenetic changes manifest in maladaptive behaviors seen in substance use disorders.
Epigenetic Tools
To dissect the complexities of epigenetic regulation, we employ a wide range of molecular techniques. From CRISPR-based tools to chromatin accessibility assays, we investigate how specific epigenetic modifications alter gene expression and brain plasticity, helping to reveal new therapeutic targets for addiction and neurodegenerative disorders.
Our Team.
We foster collaborations with leading scientists and institutions to advance our understanding of neuroepigenetics and metabolism. By working together, we aim to accelerate discoveries, share knowledge, and push the boundaries of neuroscience research.
Get in Touch
We are always looking for opportunities to collaborate with other labs and industries to advance the understanding of neuroepigenetics and substance use disorders. Interested in joining the lab or collaborating on a project? We offer postdoc and graduate student positions, as well as internships for undergraduates.
Open Positions:
-
Postdoctoral Researcher
(Epigenetics in Substance Use Disorders) -
Research Technician
(Mouse Behavioral Models & Molecular Neuroscience)
Grateful for the Support Driving Our Discoveries!
